[5][6] NHERF-2 is a scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.

This regulatory protein (factor) interacts with a sodium/hydrogen exchanger NHE3 (SLC9A3) in the brush border membrane of the proximal tubule, small intestine, and colon that plays a major role in transepithelial sodium absorption.

SLC9A3R2, as well as SLC9A3R1 and protein kinase A phosphorylation, may play a role in NHE3 regulation.

[7] Sodium-hydrogen exchange regulatory cofactor 2 has been shown to interact with SGK,[8][9] Actinin alpha 4,[10] Parathyroid hormone receptor 1,[11] Phosphoinositide-dependent kinase-1,[8] EZR,[12][13] PODXL,[14][15][16] Cystic fibrosis transmembrane conductance regulator[17] and PLCB3.

[18] This article incorporates text from the United States National Library of Medicine, which is in the public domain.