[5][6][7] It exerts anti-inflammatory effects, acts as a tumor suppressor, and antagonizes nicotinic receptors.

[8] The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence.

It is secreted into the blood[6] and is also sometimes found in semen when extracted into the female zygote which binds to the α7-acetylcholine receptor.

[8] Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder characterized by an inflammatory palmoplantar hyperkeratosis.

This is the consequence of a loss of SLURP1 which leads to a dysfunctional epithelial differentiation[9] and an increased secretion of the inflammatory cytokines TNFα, IL1, IL-6, and IL-8.