The submarine sank 27 ships in 18 patrols for a total of 16,645 gross register tons (GRT).

[5] UB-22 was mined and sunk in the same incident with the torpedoboat SMS S16 in the North Sea at 54°40′N 6°32′E / 54.667°N 6.533°E / 54.667; 6.533 on 19 January 1918 in a British minefield.

The submarine was powered by two Körting six-cylinder, four-stroke diesel engines each producing a total 280 metric horsepower (280 shp; 210 kW), a Siemens-Schuckert electric motor producing 206 kilowatts (276 shp; 280 PS), and one propeller shaft.

When submerged, she could operate for 45 nautical miles (83 km; 52 mi) at 4 knots (7.4 km/h; 4.6 mph); when surfaced, she could travel 6,650 nautical miles (12,320 km; 7,650 mi) at 5 knots (9.3 km/h; 5.8 mph).

She had a complement of twenty-one crew members and two officers and a 45-second dive time.