The highway begins in the Eastern region of city of São Paulo and ends at the county of Guararema, merging with Rodovia Presidente Dutra.

The cities served by Rodovia Ayrton Senna are Guarulhos, Itaquaquecetuba, Mogi das Cruzes, Suzano, Poá and Guararema.

Near São Paulo, special highway engineering techniques had to be used, in order to cross the natural swamp area by the Tietê River without damaging the nearby ecosystem.

13,756, gave concession to DERSA for construction and exploration of the Eastern Road, now called the Ayrton Senna Highway.

Since June 18, 2009, the concessionaire Ecopistas, of the EcoRodovias Group, is responsible for the management and administration of the highways that make up the Ayrton Senna / Carvalho Pinto Corridor: the SP-70, which links the city of São Paulo and Valley of the Paraíba, with 140 km of extension.