Rodovia Assis Chateubriand (officially designated SP-425) is a highway in the state of São Paulo, Brazil.

Its name honours the Brazilian journalist and press tycoon, Assis Chateaubriand, owner of Diários Associados.

It starts in the city of Guaíra, and passes through Barretos, Olímpia and São José do Rio Preto, where it interconnects with the Rodovia Transbrasiliana (BR-153).

The traject continues to Presidente Prudente, passing through Penápolis and Martinópolis.

It is managed and maintained by the Department of Roads of the State of São Paulo.