[5][6] It is involved in neuronal migration and differentiation[7] and plays a critical role in synaptic development,[8] brain mass and number of cortical neurons.

[9] Downregulation of srGAP2 inhibits cell–cell repulsion and enhances cell–cell contact duration.

[10] SRGAP2C, a shortened version found in early hominins and humans that only has the F-BAR domain, antagonizes its action.

[15] SRGAP2C inhibits the function of the ancestral copy, SRGAP2A, by heterodimerization and allows faster migration of neurons by interfering with filopodia production as well as slowing the rate of synaptic maturation and increasing the density of synapses in the cerebral cortex.

[14] This article on a gene on human chromosome 1 is a stub.