SS David E. Hughes (MC contract 1666) was a Liberty ship built in the United States during World War II.

She was named after David E. Hughes, an American musician, professor, and inventor.

She was operated durning World War II by the States Marine Corporation.

On 4 April 1944 she transported the Australian 4th Battalion along with other 5th Division troops from Langemak Bay, Finschafen, Papua, New Guinea, then sailed to Saidor, a 21-hour voyage.

From 1957 to 1958 and in 1968 she was used to store surplus grain with the Blidberg Rothchild Company and then Moore McCormack Lines.