SS Nathanael Greene (MC contract 146) was a Liberty ship built in the United States during World War II.

She was named after Nathanael Greene, Continental Army general famous for his service in the Southern theater of the American Revolutionary War.

She was operated by the United States Lines under charter with the Maritime Commission and War Shipping Administration.

The ship was laid down by North Carolina Shipbuilding Company in their Cape Fear River yard on May 22, 1941, then launched on January 17, 1942.

When fellow merchant ship SS Mary Luckenbach was struck by an aerial torpedo, its cargo of TNT detonated.