Discovery carried into orbit the International Microgravity Laboratory-1 (IML-1), a pressurized crewed Spacelab module, to explore in depth the complex effects of weightlessness on living organisms and materials processing.

Low gravity materials processing experiments included crystal growth from a variety of substances such as enzymes, mercury, iodine and a virus.

[4] Middeck payloads included Gelation of SOLS: Applied Microgravity Research (GOSAMR), Investigations into Polymer Membrane Processing (IPMP) and the Radiation Monitoring Experiment (RME-III).

The mission landed on January 30, 1992, 8:07:17 a.m. PST, Runway 22, Edwards Air Force Base, California, after being extended by a day for continued scientific experimentation.

The single gold star above the horizon on the right is in honor of astronaut Manley Lanier "Sonny" Carter Jr., who was killed in the crash of Atlantic Southeast Airlines Flight 2311 in Brunswick, Georgia while on a commercial airplane traveling for NASA.