4V11990064051ENSG00000159164ENSMUSG00000038486Q7L0J3Q9JIS5NM_014849NM_001278719NM_001328674NM_001328675NM_022030NP_001265648NP_001315603NP_001315604NP_055664NP_071313Synaptic vesicle glycoprotein 2A (SV2A) is a transmembrane protein belonging to a family of keratan sulfate proteoglycans, located on the synaptic vesicles of mammalian neuronal and endocrine cells.

[5][6][7] SV2A is the most widely expressed isoform of the SV2 family (which also includes the SV2B and SV2C proteins) found in all brain regions.

[8] The role of the SV2 proteins is not well understood, however they are thought to be involved in regulating vesicular processes.

[13] There is a slightly stronger colocalisation between SV2A and GABA than glutamate[14] and the association differs across brain regions and changes with developmental stages.

[15] Several PET radiotracers targeting SV2A have been developed, allowing for measuring SV2A density in-vivo: [11C]LEV, [11C]UCB-A, [11C]-UCB-H, [18F]UCB-J, [18F]Syn-VesT-1, [18F]Syn-VesT-2, and [18F]SDM-16.