3O2Q, 3O2S, 3O2T, 3ODR, 3ODS, 4H3H, 4H3K818968188ENSG00000125755ENSMUSG00000023118Q92797Q80X82NM_004819NM_026605NM_001360713NP_004810NP_001347642NP_080881Symplekin is a protein that in humans is encoded by the SYMPK gene.

The protein forms a high-molecular weight complex with components of the polyadenylation machinery.

It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex.

It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation.

The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.