To get the support of the Shirin clan he married Shirin-Bek, the widow of his older brother Akhmed who had rebelled against Mehmed in 1519.
Much of his reign was spent fighting his nephew, Mehmed's son Islam Giray, who constantly tried to take the Crimean throne.
In June 1524 he sent four Giray princes, Islam, Usbek, Buchek and Yantur to invade Lithuania.
On the way back, on 27 January, they were completely defeated on the Olshanitsa River near Kiev by Lithuanians under Konstanty Ostrogski.
In autumn 1527 Kalga Islam Giray led 40000 men against Russia, but they were blocked at the Oka River.
The conspiracy was led by Shirin Mirza Bakhtiyar-Beg and included Saadet's wife Shirin-Bek and his nephews Buchek and Yusuf Girai.
He captured Stary Krym and the surrounding uluses, executed Bakhtiyar, Buchak, Yusuf and their sons and relatives, imprisoned Shirin-Bek and appointed a new Shirin ruler.