Saba Esber was born in 1959 in Latakia, Syria, to an Orthodox Christian family.

He was ordained to the diaconate in 29 November 1984 and the priesthood in 1988, serving at the Church of the Archangel Michael in Latakia.

[1][2] His episcopacy has been in the midst of extremely difficult circumstances, as the region over which he has presided has been particularly badly damaged and materially impoverished by the Syrian civil war.

[2] From 1995 to 2006, he taught Pastoral Care and Introduction to the Old Testament at the Saint John of Damascus Institute of Theology at the University of Balamand.

[3] In 2022, his name was included among those on the nominating ballot for consideration for election by the Holy Synod of Antioch to be the metropolitan archbishop of the Antiochian Orthodox Christian Archdiocese of North America.