He served as Minister of Agriculture and Rural Development appointed by President Muhammadu Buhari until being fired on 1 September 2021.

[4][5][6] Nanono started his career as a clerk in central bank of Nigeria in kano state.

From 1980 to 1983, Nanono served as the Managing Director and Chief Executive of the Kano State Investment and Properties Limited.

Thereafter, Nanono became a Banker which he later rose to the position of a Managing Director and Chief Executive of African International Bank Limited.

Sabo Nanono worked with other various organizations before he was appointed by President Muhammadu Buhari as the Minister of Agriculture and Rural Development.