Partnering Kaitlyn Christian, Santamaria won her first WTA 125 doubles title at the 2021 L'Open 35 de Saint-Malo, defeating Hayley Carter and Luisa Stefani in the final.

[2] She claimed her maiden WTA 250 doubles crown at the 2022 Monterrey Open, playing with Catherine Harrison and overcoming Han Xinyun and Yana Sizikova in the final.

[3] Alongside Yana Sizikova, Santamaria won the doubles at the WTA 250 2023 Morocco Open with a win in the final against Lidziya Marozava and Ingrid Gamarra Martins.

[4] Partnering with Dalila Jakupović, she won the doubles title at the WTA 125 2024 Mumbai Open, defeating Arianne Hartono and Prarthana Thombare in the final.

[5] At the WTA 125 2024 Makarska International Championships, Santamaria and Iryna Shymanovich overcame Nao Hibino and Oksana Kalashnikova in a deciding champions tiebreak to win the doubles final and take the title.