[1] He has designed costumes for Bollywood films such as Guzaarish, Baabul, Laaga Chunari Mein Daag, Raavan, and English Vinglish.

During the spring of 2003, he made his first international runway, with the "Grand Winner Award" at the Mercedes-Benz New Asia Fashion week in Singapore, which paved his way to a workshop in Paris by Jean Paul Gaultier and Azzedine Alaia.

His significant achievements included his coveted showing in Browns earning him a retail place at the tiny London store voted by Vogue as the best shopping destination in the world, thereby establishing himself as one of the most promising young designers for years to come.

In 2006, Sabyasachi’s debut Spring Summer collection’07 at New York Fashion Week earned him critical acclaim and his label started selling worldwide.

He believes that Indian designers bring a flavour to the west that is no longer perceived as only exotic but also a rich blend of individuality and sensitivity.

[7] Sabyasachi closed the third edition of PCJ Delhi Couture Week (8–12 August 2012) with his New Moon collection inspired by the flavours of five cities: the world- straitjacket discipline of New York, the nostalgia of the British Raj in Kolkata, the subversive decadence of Berlin, the romanticism of Paris and bohemian flair of Barcelona.

[11] He launched his exclusive menswear collection featuring sherwanis, kurtas and headgear at the Lakme Fashion Week Spring Summer 09 Grand Finale show.

[13] Sabyasachi Mukherjee's Autumn Winter 2015 collection at Amazon India Couture Week (AICW) was a collaboration with French luxury footwear and fashion designer Christian Louboutin.

Deserts, gypsies, prostitutes, antique textiles and cultural traditions of his home town, Kolkata, have been a lifelong inspiration for this designer who believes that "clothes should just be an extension of one's intellect".

[18] On occasion, to the delight of his global audiences, the designer is known to draw inspirations from the wider world, such as exotic, indigenous ethnic European art such as the colourscapes of French impressionists like Monet and Henry Matisse in his clothes.

[citation needed] Mukherjee started a project called Save the Saree where he retails hand-woven Indian saris on a non-profit basis priced at ₹3,500 (US$40) & the entire proceed goes to the weavers of Murshidabad.

[22] Over the past two years he has also been involved in reviving cotton Benarasi saris in pure khadi and vegetable hand block prints from Bagru.

Since then, he has designed for other Bollywood movies such as Baabul, Laaga Chunari Mein Daag, Raavan, Guzaarish, Paa, No One Killed Jessica and English Vinglish.

[25] The entire trousseau collection of around 18 hand-crafted saris for Bollywood diva Vidya Balan's wedding was designed by Sabyasachi for which he specially sourced the silk from Chennai.

Chopra wore a sparkling, crimson red lehenga made of hand-cut organza flowers, French knots in silk floss, and Siam-red crystals.