The Act of Congress invoked an immediate eighteen month moratorium prohibiting the Secretary of Health, Education, and Welfare from pursuing regulatory implications by limiting the production and use of saccharin.

The Act codified a warning label requirement advocating the non-nutritive sweetener had been discovered to yield carcinogenicity in laboratory animals.

In 1958, saccharin was registered Generally Recognized As Safe (GRAS) by decree of the food additives amendment retaining the non-nutritive sweetener as a marketable product for human consumption.

In 1972 to 1973 after much growing concern among the United States population, the U.S. Food and Drug Administration and Wisconsin Alumni Research Foundation (WARF) led carcinogenic studies concluding the incidence of bladder tumors in Charles River Sprague-Dawley rat specimens.

[3][4] In 1977, the Canadian Health Protection Branch Study was completed on Charles River Sprague-Dawley rat specimens concluding lymphoma in the blood cells.