The Sacramento Wash is a major drainage of northwest Arizona in Mohave County.

The wash is east of the Black Canyon of the Colorado and drains into the south-flowing Colorado River 45 mi south of Lake Mohave, and 90 mi south of Hoover Dam at Lake Mead.

The confluence of the Sacramento Wash with the Colorado, occurs at the Topock Marsh in its southeast.

The river section containing the marsh is the Havasu National Wildlife Refuge, about 25 miles long.

The Sacramento Wash Watershed is bordered, and enclosed on the southeast and south by the Bill Williams River and its northern tributary, the Big Sandy River which drains the areas east of the Sacramento Valley.