The wooden first building, dedicated in 1882, by Bishop Northrup of Charleston, South Carolina, went up on land at North Fulton and Council Streets donated by Frances Christine Fisher, author Christian Reid.

A Hispanic ministry started in 1995, and Spanish language masses began once the numbers grew sufficiently to offer them.

[4] Sacred Heart needed a larger building and considered a site on Old Mocksville Road, but the church traded parcels of land and decided to locate near Isenberg school.

[3] On March 11, 2012, The Refuge, a Concord, North Carolina–based church, moved its Salisbury services from a movie theater into the former Sacred Heart building after doing some work.

[5] On April 7, 2013, Sacred Heart became one of ten North Carolina churches to offer Latin Mass.

[6] In June 2016, Salisbury City Council voted to rezone the former church's property for a wedding venue called The Abbey which will include retail.