Her group have also demonstrated that the central leptin-melanocortin axis plays a critical role in the regulation of human food intake.

[20] Her citation on election reads: Sadaf Farooqi has fundamentally altered our understanding of human obesity.

She has been greatly committed to the translation of her research into patient benefit and has helped to change clinical attitudes and diagnostic practice world-wide.

Obesity is one of the major public health threats facing the international community and Farooqi's research has been critical in bringing real biological insights where these were previously lacking.

Sadaf tells Jim how she discovered ten rare genetic disorders that cause severe childhood obesity and what this means for the rest of us.