Sargam continued to sing in films like Taqdeer, Pighalta Aasmaan, Raj Tilak, Karishma Kudrat Ka (in which she was the only female singer), but it was only with "Har Kisiko Nahin Milta" (Janbaaz 1986) that she was noticed.

Her main hits continued to be with Rajesh Roshan, which included 'Jab Koi Baat Bigad Jaaye' / Jurm, 'Radha Bina Hai' / Kishan Kanhaiya, and songs in Dariya Dil, Aasmaan Se Ooncha and Jaisi Karni Waisi Bharni.

[8] She got a boost from Tridev (Kalyanji – Anandji – Viju Shah) in 1989 in which she worked on "Main Teri Mohabbat Mein" and "Gajar Ne Kiya Hai Ishara".

Her other notable rhapsodic Hindi hits are "Neele Neele Ambar Par" from Kalakaar, "Jab Koi Baat Bigad Jaye" from Jurm, "Pehla Nasha" from Jo Jeeta Wohi Sikandar, "Na Kajre Ki Dhar" from Mohra, "Tere Dar Pe Sanam" from Phir Teri Kahani Yaad Aayee, "Jhinimini" from Maqbool and "Aao Na" from Kyun!

Her hits include, but not limited to, "Vennilave" from Minsara Kanavu, "Nenje Nenje" from Ratchagan, "Snehithane" from Alaipayuthey, "Swasame" from Thenali, "Konjum Mainakkale" from Kandukondain Kandukondain, "Anbae Sugama" from Paarthale Paravasam, "Deewana Deewana" from Gemini, "Vaanaville Vaanaville" from Ramanaa, "Chanakya Chanakya" from Dum, "Manmadhane Nee" from Manmadhan, "Thaiyyatha Thaiyyatha" from Thiruttu Payale, "Akkam Pakkam" from Kireedam, Enadhuyirae from Bheemaa, "Mukundha Mukundha" from Dasavathaaram, "Om Zaarare" from Kuselan, and "Kaiya Pudi" from Mynaa.

With nearly 100 tracks to her credit in Telugu, her hits include "Vennelave" from Merupu Kalalu[10], "Snehithuda" from Sakhi, "Palike Gorinkaa Chudave" from Priyuralu Pilichindi[11], "Sathamaanaa Mannadile" from Mrugaraju, "Baba Neeku Mokkutha" from Baba, "Jaajimalli Thota" and "Kommallo Koyila" from "Ninu Chusaka Nenundalenu", "Pedave Palikina Matallone" from Naani, "Ela Vacchenamma" from Sankranti, "Manasa" from Munna, "Mooga Manase" from Nava Vasantham, "Ninnena" from Salute, "Panchirey" from Konchem Ishtam Konchem Kashtam, "Kanu Paapalloo Prema" from Shambo Shiva Shambo, "Anthapuramloo" and "Avuna Neevena" from Rudhramadevi.

Another foot-tapping recent solo Tamil song is "Sutri Varum Bhoomi" from the Vidhyasagar-composed Jeyamkondaan and "En Nenjil" from Baana Kaathadi.

In 2014, Sargam sang for A. R. Rahman in India's first-ever photorealisitc motion capture film, Kochadaiiyaan, which was lip-synced by Deepika Padukone on screen.

[16] In 2013, Sadhana Sargam sang a romantic duet with Udit Narayan, "Ek Dil Hai Toota Idhar Bhi" penned by Raghvendra Singh in the music direction of Navin Manish for Rajshri Production's TV show Jhilmil Sitaaron Ka Aangan Hoga on Sahara One channel.

In 2014, Sargam recorded a bhajan, "O Kaanha Kaa Tohe Arpan Karun" penned by Raghvendra Singh in the music direction of Navin Manish for Rajshri productions TV show Mere rang mein rangne waali on Life Ok channel.

In 2015, Sargam, along with Kumar Sanu, recorded the runaway hit track, "Dard Karaara", from Dum Laga Ke Haisha in Anu Malik music.

In 2017, the duo joined once again, but to record the title track for a TV serial, Yeh Un Dinon Ki Baat Hai; the song became an instant hit.

In 2018, Sargam sang an energetic and inspiring song Houn Jau Dya in Madhuri Dixit's Marathi film debut,[17] Bucket List.

The same year to commemorate the 500th episode of the hit serial Sembaruthi, Sargam and Vijay Prakash dueted a song in the music direction of Sekar Sai Barath.

Beginning her career in the early 1980s, Sargam has sung over 15,000 film[6] and non-film songs in 36 Indian languages including Hindi, Marathi, Tamil, Bengali, Telugu, Assamese, Gujarati, Nepali, Meitei, Odia, Kannada, Malayalam and many others.

She is the only playback singer who actively participates and sings devotional and meditation songs for spiritual foundations like Prajapita Brahmakumaris Ishwariya Vishwa Vidyalaya and Satya Saibaba.

Though she has numerous tracks to her credit (more than 2000 songs in Hindi alone[6]), she had only been nominated twice for Filmfare Awards; once in 1989, for Main Teri Hoon Janam and sixteen years later, in 2005, for Aao Na.

[25] Sargam's voice is the favorite of artists like Lata Mangeshkar, Asha Bhosle, K.S.Chithra, Sunidhi Chauhan[26] A R Rahman,[27] Ilaiyaraaja, Amitabh Bachchan, Shashaa Tirupati[28] and others.