[2] He began his career in Hindi films such as Bhuvan Shome, Ankur, and Mrigaya.

Meher also acted in Byomkesh Bakshi in the episodes "Aadim Shatru (Part 1 & 2)" and "Chakrant" as Anadi Haldar and Bishupal respectively.

Meher won a National Film Award for Best Actor for Ankur.

[4] He was conferred Padma Sri by the Government of India in 2017.He is recipient of Odisha State Film Award i.e. Jayadev Award for outstanding contribution to Cinema of Odisha for the year 2008.

[5] Bhanayak [6] [7] Sadhu Meher also played characters, Anadi Haldar, in the episode "Aadim Shatru (Part 1 & 2)",[8][9] and Bishupal, in the episode "Chakrant",[10] of Byomkesh Bakshi, broadcast by Doordarshan in 1997.