The province of Diyarbakr (Persian: ولایت دیاربکر, romanized: Velāyat-e Diārbakr) was a short-lived province of the Safavid Empire located in the area of present-day Turkey.

Amida (Medieval Diyarbakır) was the provincial capital, and the seat of the Safavid governors.

It had the following administrative jurisdictions; Orfah (Urfa), Jazireh (Cizre), Kharput (Elazığ), Mardin, Sert (Siirt), and Hesn Keyfeh (Hasankeyf).