"Safe Sex" (also known as "Safe Sex (When It Comes 2 Loving U)") is a song by American band Pandora's Box, released on June 11, 1990, as the third and final single from their only studio album, Original Sin (1989).

Speaking of the song in a 1989 interview with Kerrang!, writer and producer Jim Steinman said, "I hate the term 'safe sex'.

"[2] Upon its release as a single, Ian Gittins of Melody Maker called "Safe Sex" "a song twice the size of America" from the "master of bombast" Steinman and added, "I admire his cheek while baulking at the sheer gross vulgarity of it all.

called it the "swollen condom nation anthem with a gleam in its eye" and Bob Catley of Magnum, as a guest reviewer, considered it "alright" and one he could see Bonnie Tyler singing.

As guest reviewers, Leigh Matty of Romeo's Daughter felt it was "cabaret rock" which "doesn't have any energy", whereas Willie Dowling of the Grip said it was "just pomp" with "nothing to latch on to".