Saffo is an opera in three acts by Giovanni Pacini set to a libretto by Salvadore Cammarano, which was based on a play by Franz Grillparzer, after the legend of the ancient Greek poet Sappho.

The opera was first performed at the Teatro San Carlo in Naples on 29 November 1840, and was also given in Paris at the Théâtre-Italien on 15 March 1842.

During the Poetic Games at the 42nd Olympiad (about 608 BC) a woman poet named Saffo sings so effectively against the practice of tossing felons and undesirables from a cliff on the Island of Leucadia in the hope that Apollo will catch them before they drown in the sea (the Leucadian Leap) that the god's high priest, Alcandro, is driven away in contempt.

Later, with Saffo and Apollo being in conflict, she cultivates a friendship with Climene, the daughter of Alcandro, in order to seek the priest's intercession with the god.

Saffo turns up on the clifftop at Leucadia, convinced that her continuing love for Faone is a curse from Apollo.