[8] Barker subsequently opened her self-titled YouTube account on 30 July 2015, where she still continues to create content about lifestyle and beauty, fashion and fitness.

[11] In March 2017, Saffron represented the United Kingdom in Nickelodeon's first-ever 'Social Squad of Influencers' at the 2017 Kids' Choice Awards in Los Angeles, California.

[12] In April, Barker and her family presented an original and exclusive six-episode series titled In My Day for television and video on demand service TalkTalk TV.

[14] One year later, on 9 March 2018, she was named Nickelodeon's UK representative of their KCA PrankStars, a collective of digital influencers chosen to partake in a prank war at the 2018 Kids' Choice Awards in Inglewood, California.

[18] In March 2020, Barker appeared on a one-off special edition of The Greatest Dancer for Sport Relief 2020, as a member of dance troupe Don8.

[24] In March 2023, Barker appeared in the fifth series of Channel 4's Celebrity Hunted, where she was paired up with former University Challenge contestant and mathematician Bobby Seagull.

[33][34] In the same month, Barker was one of the many UK-based social media personalities to present the four-hour long "#WithMe" YouTube livestream, discussing tips on 'how to stay upbeat through lockdown', whilst raising money for the NHS Charities Together partnership.

[35] In September 2020, Barker supported the Digital Detox Day campaign which encouraged internet users to take time off social media for 24 hours.

[36] In November 2020, she surprised a 16-year-old autistic young carer from the Isle of Sheppey, who suffers with OCD and severe anxiety, with a National Lottery Award via video message.