Saguaro's varsity football program has won an Arizona state championship fourteen times (1995, 2006, 2007, 2008, 2010, 2011, 2013, 2014, 2015, 2016, 2017, 2018, 2021, and 2023).

The varsity girls' basketball program won one state title, in 2013.

The girls' swim and dive team won one state title, in 1971.

The men's tennis teams through 2009-2013 reached the state playoffs four years in a row led by the 2013 senior class.

Saguaro High School has five disciplines in its performing arts department: orchestra, band, dance, theater, and choir.