Prior to the fall of Kabul to the hands of the Taliban, she was the first and the only woman to be directing Afghanistan's film entity.

[1] Her first professional work was a documentary, Searching for Dream, which was exhibited at the Dhaka International Film Festival in 2006.

[12] Karimi was the leading organizer of protests against Kabul Municipality's plans to demolish the once famous Cinema Park in the city.

[16] Later, she was evacuated from Kabul to Kyiv, Ukraine along with 11 individuals, thereafter writing: "My dear friends do not worry, I am fine and safe".

[17][18] Later that year Karimi settled in Italy[19] and in 2022 started teaching as a visiting professor at the National School of Cinema (CSC) in Rome.