It begins at the roundabout at Mak Pin, Sai Kung and passes through Three Fathoms Cove and Shap Sze Heung before traversing the new town of Ma On Shan and Wu Kai Sha and ending at Hang Tak Street in Tai Shui Hang.

The MTR Tuen Ma line track section between Heng On station and Wu Kai Sha station is placed directly above Sai Sha Road.

Cycling is prohibited along most of Sai Sha Road on Sundays and public holidays along the section from near Nai Chung bus stop to Mak Pin roundabout, where the road is narrow and busy with continuous double white lines and few passing places.

It originally stretched from Tai Mong Tsai to Nai Chung, hence the original name of the road was Nai Chung Access Road.

Two years later, it was open to traffic, with the connection between Sha Tin New Town and Ma On Shan finally complete.