He has released many tracks for solo projects, toured internationally, has performed with music legends like Ilaiyaraaja, SP Balasubramanyam, Shankar Mahadevan, and has been a successful playback singer for Tamil, Telugu and Kannada films.

In 2021, Sai Vignesh co-founded an Indo-Classical Contemporary Fusion band called GANDIVA alongside dancer-choreographer Kavya Muralidaran.

[12] He also was part of the chorus in the hit 2022 film Ponniyin Selvan: I. Sai Vignesh made his Telugu playback singing debut in 2022 with "Anuragam Asai" from Daarunam.

[14] Sai Vignesh toured the US in September and October of 2023 for "Simply SpB," a tribute show for legend SP Balasubramanian.

Sai Vignesh and Kavya Muralidharan debuted their indo-classical fusion group GANDIVA's inaugural live sow, Prakriti" at Bharatiya Vidya Bhavan, Mylapore, Chennai on October 22, 2024.