Set up in the fictional port city Chandraprastha, Saindhav Koneru alias "SaiKo" has a dark past, leading a quaint family life with his daughter Gayathri and caretaker Manogna.

[4] Saindhav goes back to the world of crime to extract money for Gayathri's operation and soon begins an intense battle against his past rivals, which includes a ruthless gangster Vikas Malik.

Neeshitha Nyayapati of Hindustan Times wrote "Sailesh Kolanu attempts to make a desi John Wick with Venkatesh as Saiko, but it’s Nawazuddin’s psychotic shenanigans that engage you.

"[15] Avad Mohammed of OTTplay gave 2.5/5 stars and wrote "Venkatesh is superb and Saindhav is his one-man show as his new action-packed avatar is one of the reasons to give the film a shot.

[17] Sangeetha Devi Dundoo of The Hindu wrote "Saindhav, directed by Sailesh Kolanu and headlined by Venkatesh Daggubati, is earnest in its world building and emotional family drama.