Saint-Affrique (French: [sɛ̃t‿afʁik]; Languedocien: Sant Africa) is a commune in the Aveyron department in Southern France.

The possession of Saint-Affrique was vigorously contested during the French Wars of Religion.

The Sorgues, a tributary of the Dourdou de Camarès, flows through the commune and crosses the town.

An old bridge over the Sorgue and some megaliths in the neighborhood, especially, the dolmen of Tiergues, are of antiquarian interest.

It consists of a month-long stay of at the hotel of famous chef François Decucq during which the painters could visit and paint one of the most beautiful counties in France.