Saint-Léon-sur-Vézère (French pronunciation: [sɛ̃ leɔ̃ syʁ vezɛʁ], literally Saint-Léon on Vézère; Occitan: Sent Leu de Vesera) is a commune in the Dordogne department in Nouvelle-Aquitaine in southwestern France.

It is a member of Les Plus Beaux Villages de France (The Most Beautiful Villages of France) Association.

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