Saint-Mihiel (French pronunciation: [sɛ̃ mijɛl]) is a commune in the Meuse department in the Grand Est region in Northeastern France.

A Benedictine abbey was established here in 708 or 709 by Count Wulfoalde and his wife Adalsinde.

During World War I, Saint-Mihiel was captured by the Germans in 1914, and was recaptured during the Battle of Saint-Mihiel by the American Expeditionary Forces (AEF) from 12 September to 19 September 1918.

Saint-Mihiel is known for its sculptures by Renaissance sculptor Ligier Richier (1500–1567).

Saint-Mihiel serves both as the starting and ending point of the 2014 video game Valiant Hearts: The Great War.