Saint-Pie-de-Guire (French pronunciation: [sɛ̃ pi də ɡiʁ]) is a parish municipality in the Centre-du-Québec region of southwestern Quebec.

The population as of the Canada 2011 Census was 456.

In the 2021 Census of Population conducted by Statistics Canada, Saint-Pie-de-Guire had a population of 446 living in 185 of its 206 total private dwellings, a change of -0.9% from its 2016 population of 450.

With a land area of 51.27 km2 (19.80 sq mi), it had a population density of 8.7/km2 (22.5/sq mi) in 2021.

[5] Population trend:[6] Mother tongue language (2006)[7]