Saint-Priest (French pronunciation: [sɛ̃ pʁijɛst] ⓘ; Arpitan: Sant-Priést) is a commune in the Metropolis of Lyon in the Auvergne-Rhône-Alpes region in eastern France.

It is the fourth-largest suburb of the city of Lyon, and is located to its southeast side.

The Saint-Priest station is served by local trains to Lyon and Saint-André-le-Gaz.