Saint-Sixt (French pronunciation: [sɛ̃ sikst]; Arpitan: San-Fi) is a commune in the Haute-Savoie department of the Auvergne-Rhône-Alpes region in Southeastern France.

It is situated just east of La Roche-sur-Foron and north of the Bornes Massif.

As of 2019, its population was 1,018.

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