Located in the crossing of Saint Peter Basilica in Rome, the work depicts Andrew the Apostle leaning over the crux decussata of his martyrdom.

Duquesnoy's St Andrew is one of four colossal statues beneath the dome of St. Peter, standing opposite to Bernini's less restrained Saint Longinus.

[1] In a letter to Duquesnoy by Peter Paul Rubens, which the latter penned to thank the former for the models after the Van den Eynde's putti,[1][2] Rubens praises the beauty of the Van den Eynde's putti and refers to the fame of the Saint Andrew, but he makes no mention of the Saint Susanna.

[1] The full-scale stucco model of St. Andrew was unveiled in its intended niche on December 19, 1629, in front of the Pope and the attending cardinals.

[1] In 1968, Irving Lavin noted that in the official transcription of the May 1628 meeting, it was recorded that the model chosen by the Pope for Saint Andrew was in fact Gian Lorenzo Bernini's.

[1][7] The large, muscular, Laocoön-like torso of the Saint Andrew, standing leaned against his carefully detailed saltire cross, is indeed an "almost direct quotation of the ancient sculpture; so unlike with Bernini's solutions, yet so congruent with Duquesnoy's ideas about the Greek manner.