In November 1843, congregation foundress Saint Mother Theodore Guerin and Sister Mary Cecilia Bailly were returning from France with three French postulants after a fundraising trip.

Under the leadership of General Superior Mother Mary Ephrem Glenn, a sturdier stone chapel was built on the same site with the same 15' by 15' dimensions.

Every July 25 since 1844, on the eve of the Feast of St. Anne, the sisters gather for a solemn procession to the chapel in honor of the saint.

These designs include a depiction of the Nashville, a map of Indiana showing the mission established up to 1876, and an illustration of the all-seeing Eye of God.

The floor is tiled with sea green and coral-colored floral patterns, and a painted nautilus border trims the top of the walls.