Sant'Antonio Abate is an oil-on-canvas painting by the Italian Baroque painter Mattia Preti, executed c. 1628.

It is part of the Collezione M curated by the Fondazione Sorgente Group in Rome, Italy.

The oval painting depicts a half-bust of the eremitic early Christian monk St Anthony Abbot.

The elderly man is dressed in a sober dark cloak with hood, setting apart his white beard.

The painting has also been described as possibly depicting St Francis of Paola.