The main U.S. post office for Clarksville is in the St. Bethlehem community on U.S. Route 79 (Wilma Rudolph Bvd.).
It is home to most of Clarksville's restaurants, retail businesses, and industries, with U.S. Highway 79 (named Wilma Rudolph Boulevard in this area for the Olympic sprinter), running directly through the center.
The Governor's Square Mall (not to be confused with the Governor's Square Mall of Tallahassee, Florida), which is the center of shopping activity in St. Bethlehem, one of two K-Marts, Sam's Club (located further north), and one of three Wal-Marts in the county are located off this street.
During the Civil War, the Confederate States of America established Camp Boone at St. Bethlehem in 1861, along the Guthrie-Russellville Road (today SR 79) as a camp for the recruitment of Kentucky soldiers into the Confederate Army.
St. Bethlehem can be easily accessed via Interstate 24 Exits 1, 4, and 8 in Tennessee, and by TN 374 from West and South Clarksville.