Saint Denis Street (officially in French: Rue Saint-Denis) is a major north–south thoroughfare in Montreal, Quebec.

It extends from the Notre-Dame-de-Bon-Secours Chapel on Saint Paul Street in Old Montreal to the bank of the Rivière des Prairies at the north end of the island.

Saint-Denis serves as one of the primary thoroughfares of both the Latin Quarter, where it plays host to a number of bars and restaurants, to the Plateau Mont-Royal, where it is known as one of the best places to view Montreal's distinct style of architecture.

In the Quartier Latin, its vocation is primarily touristic and leisure-related, with restaurants and theatres located along this stretch.

It was deserted by academics following the relocation of Université of Montreal and École Polytechnique on the northern slope of Mount Royal.

From the late 1970s, the academic character of the neighbourhood returned with the construction of pavilions for the Université du Québec à Montréal, around the steeple of the old Saint Jacques Cathedral.