[4] St. Francois County comprises the Farmington Micropolitan Statistical Area, which is also included in the St. Louis–St.

A former county seal, used from 2018 to 2022, was posted on the subreddit r/CrappyDesign where it received considerable attention and was covered by local and national news organizations.

[7] The seal was unanimously approved by the county commission and was used on government signage and vehicles.

[8] The seal featured clip art-style[9] images of a bald eagle atop the American flag, a pickaxe and shovel, a Bible and Christian cross, and an outline of the county.

In response to the attention it received, the county held a contest to redesign the seal.

Gallaher requested that the redesign make reference to the parks in the county as well as include elements from the old seal.

The most predominant denominations among residents in St. Francois County who adhere to a religion are Southern Baptists (45.48%), Roman Catholics (14.94%), and Methodists (8.37%).

[19] The Republican Party predominantly controls politics at the local level in St. Francois County.

Smith won a special election on Tuesday, June 4, 2013, to finish out the remaining term of U.S. Representative Jo Ann Emerson (R-Cape Girardeau).

During the 2020 COVID-19 pandemic, the head of the St. Francois County Public Health Department described being driven to resign from her position by residents who refused to "accept the reality of the pandemic" and made “cowardly“ anonymous threats against her and her family.