Born Rosanna Negusanti to a noble family from Faenza, she was married at the age of fifteen to a nobleman named Ugoletto (Ugonotto) dei Caccianemici (d. 1256).

[1] In 1254 she became an anchoress in a cell attached to the Vallumbrosan church of Saint Apollinaris in Faenza, where she lived as a hermit or recluse for twelve years.

In 1266, however, at the request of the abbot-general she founded a Vallumbrosan monastery (which became called Santa Maria Novella alla Malta) outside Faenza and became its abbess.

[1] The convent was decorated by the artist Buonamico Buffalmacco,[3] and consecrated in 1297 by the bishop Francesco Monaldeschi.

In 1972, the relics of Humility were translated to the Monastery of the Holy Spirit in Bagno a Ripoli, on the outskirts of Florence.