Saint Jerome in His Study is a c. 1445–1446 painting by Colantonio, a painter active in Naples between 1440 and around 1470.

It shows the strong influence of contemporary Flemish and French art on the painter and originally formed part of a multi-panel altarpiece for the church of San Lorenzo Maggiore, later split up.

The work is now in the National Museum of Capodimonte.

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