The North-Western State Medical University named after I. I. Mechnikov (NWSMU), until 2011 St. Petersburg I. I. Mechnikov State Medical Academy (SPSMA), is a public university located in St. Petersburg, Russian Federation.

The NWSMU is one of the oldest and largest Russian Higher Medical Schools.

It is often called the Second Medical College in St. Petersburg because of its renaming in 1920, relative to Saint Petersburg State Medical University, which is called the First Medical College.

The university was established in 2011 following a merger of SPSMA with the St. Petersburg Medical Academy for Postgraduate Studies.

The NWSMU was established in 1907 under the direction of academician Vladimir Bekhterev and developed by the Russian Government through the Ministry of Health on the basis of the laws of Russian Federation.