In 2021, nurses went on strike at the hospital, which by this time was owned by Tenet Healthcare.

[2] According to the management of the hospital, a labor contract proposal between the two involved parties included a "substantial" pay increase for the nurses.

[3][4] The management of the hospital claims that the demands from the Union's end are "unreasonable" and claimed that the hospital has "one of the most generous staffing ratios in the state".

However, the union representatives rejected such a claim, arguing that nurses routinely have to attend to five patients at a time and that the staffing levels at the nearby UMass Memorial Medical Center are lower than those at Saint Vincent.

[6] As of October 2021, all parties have reached an agreement, with the exception of Tenet Healthcare's refusal to lay off the replacement nurses.