Sainte-Florence (French pronunciation: [sɛ̃t flɔʁɑ̃s];) is a Canadian forestry village in the province of Quebec, located in the Matapédia Valley in the Gaspé Peninsula.

The municipality had a population of 367 as of the Canada 2021 Census.

In the 2021 Census of Population conducted by Statistics Canada, Sainte-Florence had a population of 367 living in 187 of its 207 total private dwellings, a change of -4.4% from its 2016 population of 384.

With a land area of 103.48 km2 (39.95 sq mi), it had a population density of 3.5/km2 (9.2/sq mi) in 2021.

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