Sainte-Marguerite-Marie (French pronunciation: [sɛ̃t maʁɡəʁit maʁi]) is a municipality in the Canadian province of Quebec, located in La Matapédia Regional Council Municipality.

[1] The municipality had a population of 183 at the Canada 2021 Census.

Canada Census data before 2001:[7] Provincially it is part of the riding of Matane-Matapédia.

In the 2022 Quebec general election the incumbent MNA Pascal Bérubé, of the Parti Québécois, was re-elected to represent the population of Sainte-Marguerite-Marie in the National Assembly of Quebec.

In the 2021 Canadian federal election, the incumbent Kristina Michaud of the Bloc Québécois was re-elected to represent the population Sainte-Marguerite-Marie in the House of Commons of Canada.