Jose Gomez of Huerce, Spain, when he was only 26 years old, commenced the construction of the present-day cathedral in 1840.

The foundation of the church was laid by him, putting up solid 2.40 meters-thick stone and brick walls and roofed the building with nipa.

Executed in the Baroque-Romanesque style, the ground plan of the church exhibits a cruciform shape and has a circular dome above the center of the transept.

Francisco Juan Moreno de Montalbanejo expanded the height, length, and width of the church.

Antonio Sanchez, parish priest from 1894 to 1898, beautified the church's interior and sanctuary was paved with marble, and the retablo was built.

Jose Diasnes returned to Calbayog as its parish priest after the Philippine-American War ended in 1902.

Pablo Singzon, the appointed bishop of the newly created Diocese of Samar and Leyte, and Fr.

Mosaic and geometrical designs accented the walls while the dome and the ceiling were adorned with the images of Sts.